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Three-Month Interim Analysis of Ketogenic Metabolic Therapy in Japanese ADPKD Patients

Three-Month Interim Analysis of Ketogenic Metabolic Therapy in Japanese ADPKD Patients This interim analysis published in the Journal of the American Society Of Nephrology (JASN) and presented at the latest ASN Kidney Week, reports early results from the first clinical study in Asia testing ketogenic metabolic therapy, using a ketogenic diet...

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Inflammation and Cyst Expansion in Polycystic Kidney Disease

Inflammation and Cyst Expansion in Polycystic Kidney Disease This study published in Journal of the American Society of Nephrology (JASN), explored how inflammation contributes to cyst growth in polycystic kidney disease (PKD).Using mouse models with different genetic causes of PKD, researchers found that immune cells called macrophages build...

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Citrate in Autosomal Dominant Polycystic Kidney Disease: Biomarker or Therapeutic Agent

Citrate in Autosomal Dominant Polycystic Kidney Disease: Biomarker or Therapeutic Agent This review published in Nephrology and Hypertension examines the role of urinary citrate in autosomal dominant polycystic kidney disease (ADPKD), with a focus on its potential as both a prognostic biomarker and a therapeutic target.Evidence from experimental and clinical studies...

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High BMI and Aging Jointly Drive the Rising Global Burden of Chronic Kidney Disease

High BMI and Aging Jointly Drive the Rising Global Burden of Chronic Kidney Disease Using data from the Global Burden of Disease Study 2021, this study from Frontiers examined trends in chronic kidney disease (CKD) attributable to high body mass index (BMI) from 1990 to 2021 and projected burden through 2050.In 2021 alone, high...

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Urine Alkalization Enhances Gout Management Beyond Uric Acid Control

Urine Alkalization Enhances Gout Management Beyond Uric Acid Control Rheumatology- Oxford Academic Journal, Published  a prospective cohort study that investigated whether adding urine alkalization to urate-lowering therapy (ULT) improves outcomes in men with gout and low urinary pH (<6.2).A total of 385 participants initiating febuxostat therapy were divided into...

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