Using data from the Global Burden of Disease Study 2021, this study from Frontiers examined trends in chronic kidney disease (CKD) attributable to high body mass index (BMI) from 1990 to 2021 and projected burden through 2050.

In 2021 alone, high BMI contributed to over 418,000 CKD-related deaths and 1.04 million disability-adjusted life years (DALYs).

Both age-standardized mortality and DALY rates showed a steady increase over time, with the burden disproportionately affecting males and varying significantly by region and socio-demographic index.

A decomposition analysis revealed that population aging plays a key role in the growing CKD burden.

Why is this important?

This study highlights the dual impact of obesity and aging on kidney health, with projections suggesting continued increases in CKD burden globally. Addressing high BMI through prevention and intervention strategies, especially in aging populations, may be critical to reducing CKD-related disability and death in the decades ahead.

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